GHRP-2 is a growth hormone secretagogue. This means that it stimulates the body to release growth hormone. GHRP-2 is a synthetic analog of ghrelin. Like ghrelin it stimulates the secretion of GH in the anterior pituitary gland. Like ghrelin is synergistic with the endogenous hormone (secreted by the body) called GHRH (growth hormone releasing hormone) and also with the synthetic versions of GHRH as Geref or GRF (1-29).
While GHRP-2 and other synthetic analogs of ghrelin increase the release of growth hormone by inhibiting somatostatin, GHRH increases growth hormone production by other means. that is why such drugs go so well together.
Unlike ghrelin, GHRP-2 is not lipogenic, which means it does not favor fat gain. While ghrelin plays a role in inducing hunger, GHRP-2 as analog of it, does not increase appetite.
GHRP-2 is synergistic with GHRH due to their side effects on the hypothalamic neurons. The level of growth hormone secreted when GHRP-2 and GHRH are administered together is higher than if each drug would be taken separately.
Neuronal stimulation in the hypothalamus takes about one hour after GHRP-2 is administered, causing a massive secretion of growth hormone, which fades gradually 3 hours after taking the drug. This release of growth hormone resembles the body's natural pulses, and in many ways is superior to taking synthetic HGH , which has a half-life of 8 hours. Cell desensitization is more likely to occur when human growth hormone is longer in circulation.
The decline in the natural production of growth hormone, which happens with aging is not a consequence of the inability of the pituitary to produce growth hormone but rather an impaired signaling to it. The pituitary gland of older people can produce the same amount of growth hormone with the same frequency as in younger people, but the elements that signal the start of the production, ghrelin and GHRH, are present in much smaller amounts compared to a younger person. So GHRP-2 is effective in people of any age.
GHRP-2 has a protective effect on the liver and has anti-inflammatory propreties; apparently it can increase the production of IGF-1.
The optimal dose for GHRP-2 is 1 mcg / kg of bodyweight, but most bodybuilders will use 100 mcg/day. It is administered trough subcutaneous injections twice daily, 100 mcg in the morning and 100 mcg in the evening. Before and after administration do not eat anything for 30 minutes.
The results are more pronunced with GHRP-2 (or any drug in this class, such as GHRP-6 - a drug very similar, but who can induce a sensation of hunger higher) if is stacked with GHRH ( Geref , e.g). The two drugs are synergistic, due to the way they act. When GHRP-2 is administered it sends asignal to the pituitary gland to release more growth hormone. GHRH increases evgen more this signal, amplify it. Taken alone, GHRH has a low impact on growth hormone secretion, but when combined GHRP-2 the signal is very strong. The two drugs must be taken in equal doses (100 mcg GHRP-2 and 100 mcg GHRH).
This combination creates a pulse of three hours, which is equal to 8 I.U. of synthetic HGH.
Because of lower costs (production is much cheaper compared to HGH ) and fewer possible side effects (most common side effect is sore joints) peptides such as GHRP-2 may soon replace synthetic growth hormone.
WARNING! The use of human growth hormone can be very risky. Fortunately, there are natural alternatives that can stimulate the natural secretion of growth hormone, with no side effects and risks. And often at very good prices. Such options are GH Balance or Somatodrol.